Etodolac - has an anti-inflammatory, analgesic, antipyretic effect. The medicine is prescribed in case of rheumatoid arthritis, ankylosing spondylitis, arthrosis with pain syndrome and restriction of movements, acute and chronic osteoarthritis.
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Etodolac product description
Etodolac is a non-steroidal anti-inflammatory medication manufactured in tablets. The main purpose of the tablets is analgesic and antipyretic. This is an indoleacetic acid derivative that is distinguished by the presence of a tetrahydropyranol nucleus. This substance has an anti-inflammatory, analgesic, antipyretic effect. The drug reduces the production of prostaglandins from arachidonic acid by blocking the enzyme cyclooxygenase. This mechanism provides a decrease in the receptor sensitivity to mediators of pain (bradykinin, histamine), a decrease in exudation, migration of leukocytes, and sensitivity of thermoregulatory centers to the action of endogenous pyrogens. Etodolac has a moderate specificity with respect to COX-2, due to which it acts mainly in the centers of inflammation. The use of Etodolac is very popular due to its active influences on the three elements of the inflammatory process: pain, temperature and the cause of inflammation. This medical preparation is used for emergency or prolonged therapy of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis. It is also consumed to eliminate pain syndrome of any etiology.
Etodolac safety information
As with other non-steroidal anti-inflammatory preparations, it is advisable to take Etodolac after meals or with food, or antacid agents to reduce irritation of the gastrointestinal mucosa, especially with prolonged admission. There are known cases of hypersensitivity reactions to NVS or acetylsalicylic acid, anesthesia after aortocoronary shunting, special sensitivity to any of the elements of the composition, an ulcer active or recurrent, in the active phase, severe liver, kidney or heart failure.
The medication is also not used for the treatment of minors breastfeeding or pregnant.
The combination with other NSAIDs increases the risk of abdominal bleeding and peptic ulcer of the stomach. Etodolac enhances the results of the oral anticoagulants based on coumarin or indanedione derivatives. Increases the concentration of lithium in the blood plasma and increases the hematological toxicity of methotrexate.
Cefamandole, cefoperazone, cefotetan, valproic acid can lead to hypoprothrombinemia, and plicamycin or valproic acid can suppress platelet aggregation. The medical remedy is able to enhance the hypoglycemic effect of sulfonamides.
Among the other contraindications - peptic ulcer of the stomach, duodenum; bronchial asthma, rhinitis, hives in anamnesis, which occurred after taking acetylsalicylic acid or other NSAIDs; a severe allergic reaction in the anamnesis, for example, an anaphylactic reaction or angioedema.
Etodolac side effects
Side reactions, such as of many medications of this group, are present in this medication, among them there is nausea, vomiting (possibly with blood), fastening or upset of the stool, ulceration of the walls of the stomach, intestines, ulcerative stomatitis, weakness, dizziness, allergies on the skin and others, they are clearly marked with instructions. The reduction of the likelihood of their occurrence can be achieved by the correction of the dosage for an intake.