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Heart Disease

Active ingredient: Diltiazem

Cardizem, derivative benzothiazepine, has anti-anginal, antiarrhytmic and hypotensive effect. It is prescribed at arterial hypertension: after myocardial infarction, at patients with accompanying stenocardia when beta adrenoblockers, are contraindicative at patients with diabetic nephropathy, in cases when ACE inhibitors are contraindicated; angina of effort, Prinzmetal's angina; prevention of a coronary spasm when carrying out a coronary angiography or operation of aortocoronary shunting.

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14-21 DAYS
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Availability: In Stock (51 packs)

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Cardizem Product Description

Drug Uses

Cardizem is an oral vasodilator with antianginal and antihypertensive activity. Cardizem tablets and capsules are used for reduction of high blood pressure and management of angina in adults and elderly patients.

Cardizem is effective in the treatment of mild to moderate essential hypertension, as well as in the treatment of chronic stable angina (angina pectoris) due to coronary artery disease (CAD) or coronary artery spasm.

  • To prevent major adverse cardiac events, Cardizem can be used in combination with other cardiovascular agents.
  • To stop acute angina attacks, Cardizem can be used together with sublingual glyceryl trinitrate (GTN or nitroglycerin).
  • To enhance the antianginal and antihypertensive effects of Cardizem, the combination drug therapy may include beta-blockers (such as Propranolol).

Missed Dose

If you forget to take a dose of your antihypertensive / antianginal agent, take Cardizem tablet or capsule as soon as possible. However, if it is almost time for the next dose of Cardizem, skip the missed dose of your medication and go back to the assigned dosing regimen.

More Information

Cardizem has antiarrhythmic effect but not approved for the treatment of arrhythmias. However, this medication can be prescribed for some patients with heart rhythm problems as an antiarrhythmic agent for «off-label» use.

Cardizem does not affect the causes and mechanisms of vasospastic or unstable angina. Therefore, to treat these forms of angina, other antianginal agents should be used instead of Cardizem.


Cardizem tablets and capsules should be stored in a dry place, protected from light and moisture, at room temperature to 30°C (86°F), out of sight and reach of children.

Cardizem Safety Information


Cardizem can reduce heart rate, cause symptomatic hypotension or reversible liver failure. These adverse effects are very rare and can be caused both by Cardizem and by associated risk factors.When using Cardizem in combination with other cardiovascular agents, the risk of changes in heart rate is higher than in the use of Cardizem as a monotherapy.


Cardizem review is provided purely as a source of information, so it should not be considered as a substitute for consultation with a cardiologist or treating physician. The online pharmacy will not be held liable for any damages incurred because of any actions based on the use of information about antianginal / antihypertensive / antiarrhythmic Cardizem agent.

Cardizem Side Effects

In addition to the treating effect, Cardizem may cause some unwanted effects of various severity. The most common are: headache (5%), oedema (5%), dizziness (4%) and asthenia (3%). Less frequently, Cardizem may cause flushing (2%), AV block (2%), bradycardia (2%) and rash (1%).

During the process of Cardizem therapy, the patients with hypertension can detect such unwanted effects as dyspepsia, edema and constipation. When treating angina, Cardizem use can lead to palpitations, nausea, as well as sleep disorders, such as insomnia.

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Cardizem ER - extended release tablets with diltiazem. Antiarrhytmic action is caused by learned suppression of transport of Ca2+ in heart tissues that leads to lengthening of the effective refractory period and delay of carrying out in AV nodosity. Hypotensive action is caused by dilatation of resistive vessels and decrease in TPR. Extent of decrease in arterial blood pressure is correlated with its initial level. It has the minimum influence on smooth muscles of GIT. During long (8 months) therapies tolerance does not develop.


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Capoten suppresses activity of angiotensin-converting-enzyme therefore angiotensin-I turns into angiotensin II - substance which has strong vasoconstrictive action. Capoten reduces secretion of Aldosteronum in suprarenal cortex, at the same time the delay of sodium and water in an organism decreases. Capoten slows down process of bradykinin destruction and promotes increase of E2 prostaglandin, and also nitrogen oxide that causes vasodilating action. Thanks to these effects it is decreased the increased arterial pressure, the general peripheric resistance decreases, pressure in the right auricle, in a small circle of blood circulation decreases and cordial emission increases.


Pharmacological influence of Calan is explained by braking of a flow of calcium ions through the slowed-down calcic tubules of cellular covers of smooth muscle structure of vessels and a cardiac muscle. Calan is prescribed if it was diagnosed paroxysmal supraventricular tachycardia (except WPW syndrome), sinus tachycardia, premature atrial contraction, blinking and atrial flutter, stenocardia (inc. stress, postinfarction), arterial hypertension, hypertensive crisis, idiopathic hypertrophic subaortic stenosis, hypertrophic cardiomyopathy.


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