It is used for the treatment of spasticity in multiple sclerosis, strokes, TBI, meningitis, spinal diseases (infectious, degenerative, tumor and traumatic genesis), in children's cerebral palsy; alcoholism (affective disorders). Reducing the excitability of the end sections of the afferent sensitive fibers and suppressing the intermediate neurons, inhibits the mono- and polysynaptic transmission of nerve impulses; reduces the preliminary stress of the muscle spindles.
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Lioresal Product Description
Lioresal is an antispastic drug, acting at the spinal level and reducing painful flexor spasms and spontaneous clonus in patients with muscle spasticity. In contrast to the centrally acting antispastic drugs, Lioresal has no sedative effect and improves the patient’s overall health.
Lioresal is prescribed to pediatric patients (newborns) and adult patients (including elderly) for relief of spasticity of voluntary muscle, caused by multiple sclerosis, cerebrovascular accidents, spinal lesions and traumatic head injury.
Usually, the treatment of spasticity is started with the lowest dose of Lioresal. The recommended initial dose for adults is 15 mg per day (three Lioresal 5mg tablets). Thereafter, the dosage of the antispastic drug is gradually increased every three days at the average by 15mg.
Typically, to achieve the desired anti-spastic effect, the sufficient daily dose is 60mg, but some patients may require a daily Lioresal dose of 100 mg.
If you’ve forgotten to take a scheduled dose of Lioresal, take it as soon as possible and return to your regular dosing schedule. Do not take two doses of Lioresal at the same time or close to each other. In case it is almost time for your next dose of the antispastic agent, just wait for the proper time and skip the forgotten dose of Lioresal.
Because of high risk of renal dysfunction and higher CNS toxicity, the elderly patients should be treated with low doses of Lioresal (15 to 30 mg per day). The initial pediatric dose of Lioresal is adjusted depending on the child's body weight, and usually it makes approximately 0.3mg/kg a day. Lioresal daily dose can be gradually increased, but no more often than once a week. The maximum recommended dose of Lioresal for children is 40 to 60 mg per day.
Lioresal should be kept in a tight container with a child-resistant closure, in a warm dry place. It is strictly advised to avoid freezing or heating the tablets Lioresal. The recommended temperature for storage of antispastic agent Lioresal varies from 15°C to 30°C.
Lioresal Safety Information
The patients with epilepsy or a history of convulsive disorder are recommended to take extreme caution while using Lioresal. Lioresal may exacerbate epileptic manifestations and deterioration of seizure control. Lioresal can be used, provided that the patient has an appropriate anticonvulsant therapy.
Lioresal may worsen the state of the patients suffering from schizophrenia, Parkinson's disease, depressive or manic disorders. Therefore, the patients with psychiatric and nervous system disorders should be careful passing the treatment of spasticity with Lioresal under thorough medical supervision.
The research and clinical material, published in the review of Lioresal, is provided for understanding and information about spasticity treatment, and is not intended to replace a personal medical advice by the health care professional. The online pharmacy shall not be liable for any damages, problems and loss, arising from the use of materials of Lioresal antispastic agent.
Lioresal Side Effects
At the beginning of the treatment of spinal cord diseases with Lioresal pills, the following adverse events may appear: weakness, somnolence, muscular hypotonia, fatigue, nausea, sedation or dizziness. Typically, these adverse events occur in high doses of Lioresal, so their frequency and intensity can be managed by reducing the dosage. Lioresal causes mild adverse events which do not require withdrawal of the antispastic agent. Sometimes such adverse events as hallucinations and confusion can be observed in the elderly and the patients with cerebrovascular disorders during Lioresal therapy.